Potassium Carbonate → HCID 71093757, compound

HRID 1409733Notes

Reaction equation

HRID 1409733 reaction equation
[CH3:1][C:2]1[NH:3][CH:4]=[C:5]([C:7]([OH:9])=[O:8])[N:6]=1.Cl[C:11]1[N:16]=[CH:15][C:14]([C:17]#[N:18])=[CH:13][CH:12]=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[C:17]([C:14]1[CH:13]=[CH:12][C:11]([N:3]2[CH:4]=[C:5]([C:7]([OH:9])=[O:8])[N:6]=[C:2]2[CH3:1])=[N:16][CH:15]=1)#[N:18]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 51520946-Chloro-3-pyridinecarbonitrileHCID 178433052HCID 178433052, compound

Product 1

HCID 71093757HCID 71093757, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 2-methyl-1H-imidazole-4-carboxylic acid (490 mg), 6-chloropyridine-3-carbonitrile (800 mg), and K2CO3 (1.1 g) in DMF (6 mL) is heated to 100° C. overnight. The crude product is purified by HPLC. LC (method 20): tR=0.73 min; Mass spectrum (APCI): m/z=229 [M+H]+.

Workup

  1. customThe crude product is purified by HPLC

Sources & evidence

ORD record
ord-1e9f4a799ad84912aa02fced80c64607
Source dataset
uspto-grants-2014_12
Patent number
US08921398B2

Reaction notes

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