Methyl 3,3-dimethoxypropionate → HCID 178495579, compound

HRID 1409911Notes

Reaction equation

HRID 1409911 reaction equation
Cl.Cl.[O:3]1[C:8]2=[CH:9][CH:10]=[CH:11][C:7]2=[CH:6][C:5]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][N:13]2[CH2:18][CH2:19][C@H:20]2[CH2:25][CH2:24][C@H:23]([NH2:26])[CH2:22][CH2:21]2)=[CH:4]1.[CH3:27][O:28][CH:29]([O:35][CH3:36])[CH2:30][C:31](OC)=[O:32]>>[O:3]1[C:8]2=[CH:9][CH:10]=[CH:11][C:7]2=[CH:6][C:5]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][N:13]2[CH2:18][CH2:19][C@H:20]2[CH2:21][CH2:22][C@H:23]([NH:26][C:31](=[O:32])[CH2:30][CH:29]([O:35][CH3:36])[O:28][CH3:27])[CH2:24][CH2:25]2)=[CH:4]1

Participants

3

Reactant 2

HCID 81924Methyl 3,3-dimethoxypropionateHCID 178478713HCID 178478713, compound2×

Product 1

HCID 178495579HCID 178495579, compound

Procedure

The title compound, white solid (71 mg, 64%), MS (ISP) m/z=443.4 [(M+H)+], mp 148° C., was prepared in accordance with the general method of example 46 from trans-4-[2-(4-benzofuran-3-yl-piperidin-1-yl)-ethyl]-cyclohexylamine dihydrochloride (intermediate A) (100 mg, 0.25 mmol) and methyl 3,3-dimethoxy-propanoate.

Sources & evidence

ORD record
ord-668b68ebced341e684559715c58e0195
Source dataset
uspto-grants-2014_12
Patent number
US08921397B2

Reaction notes

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