Hydrochloric Acid → HCID 178508304, compound

HRID 1410179Notes

Reaction equation

HRID 1410179 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]([NH:15]C(=O)C)[NH:13][CH:14]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2].Cl.[OH-].[Na+]>CCO>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([C:10]2[N:11]=[C:12]([NH2:15])[NH:13][CH:14]=2)=[CH:8][CH:9]=1)([O-:3])=[O:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178474423HCID 178474423, compound

Product 1

HCID 178508304HCID 178508304, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.7 g (11 mmol) N-[4-(4-nitrophenyl)-1H-imidazole-2-yl]acetamide was taken up in 30 mL EtOH, combined with 50 mL 50% hydrochloric acid, and stirred for 3 hr under reflux. The batch was made alkaline with 6 M NaOH and extracted with ethyl acetate. The organic phase was dried (MgSO4) [and] concentrated. The residue (0.9 g) was further used without purification.

Workup

  1. temperatureunder reflux
  2. extractionextracted with ethyl acetate
  3. dry with materialThe organic phase was dried (MgSO4) [and]
  4. concentrationconcentrated
  5. customThe residue (0.9 g) was further used without purification

Sources & evidence

ORD record
ord-d096e964d142409e950b7cc89224ad16
Source dataset
uspto-grants-2014_12
Patent number
US08921406B2

Reaction notes

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