huagongshe.com
HRID1410188

反应详情

EQUATION

反应方程式

HRID 1410188 反应方程式

REACTANTS

反应物

3
Acetyl chloride 分子结构式
HCID6367

Acetyl chloride

C2H3ClO

2 次

Sodium Bicarbonate 分子结构式
HCID516892

Sodium Bicarbonate

CHNaO3

Benzenemethanamine, 4-chloro-N-methyl-3-nitro- 分子结构式
HCID28338349

Benzenemethanamine, 4-chloro-N-methyl-3-nitro-

C8H9ClN2O2

PRODUCTS

产物

1
N-[1-(4-Chloro-3-nitrophenyl)ethyl]acetamide 分子结构式
HCID59529853

N-[1-(4-Chloro-3-nitrophenyl)ethyl]acetamide

C10H11ClN2O3

AUXILIARIES

试剂、催化剂与溶剂

1
Tetrahydrofuran 分子结构式
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

TEA (0.28 mL, 2.0 mmol) followed by acetylchloride (96 L, 1.3 mmol) were added to 4-chloro-methyl-3-nitrobenzylamine (0.27 g, 1.3 mmol) in THF (5 mL) at rt. The mixture was stirred at rt for 3.5 h and additional acetylchloride (20 L, 0.27 mmol) was added. After 1 h at rt, NaHCO3 (aq, 5%) was added and the mixture extracted with EtOAc.

WORKUP

后处理

  1. waitAfter 1 h at rt
  2. extractionthe mixture extracted with EtOAc