HCID 67230022, compound → HCID 59529808, compound

HRID 1410193Notes

Reaction equation

HRID 1410193 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:10][C:11](=[O:13])[CH3:12])[CH3:9])=[CH:4][C:3]=1[N:14]=[C:15]=[S:16].[NH2:17][C:18]1[CH:19]=[C:20]([CH:31]=[CH:32][C:33]=1[NH:34][CH3:35])[C:21]([NH:23][C:24]1[CH:29]=[CH:28][C:27]([Br:30])=[CH:26][CH:25]=1)=[O:22]>CN(C=O)C>[C:11]([NH:10][CH:8]([C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([NH:14][C:15](=[S:16])[NH:17][C:18]2[CH:19]=[C:20]([CH:31]=[CH:32][C:33]=2[NH:34][CH3:35])[C:21]([NH:23][C:24]2[CH:25]=[CH:26][C:27]([Br:30])=[CH:28][CH:29]=2)=[O:22])[CH:4]=1)[CH3:9])(=[O:13])[CH3:12]

Participants

4

Reactant 2

HCID 67230022HCID 67230022, compoundHCID 86646334HCID 86646334, compound

Product 1

HCID 59529808HCID 59529808, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

N-[1-(4-Chloro-3-isothiocyanatophenyl)ethyl]acetamide in DMF (2 mL) was added to a mixture of 3-amino-N-(4-bromophenyl)-4-methylaminobenzamide (87 mg, 0.2 mmol, crude material from the step above) in DMF (2 mL) at rt. The mixture was stirred at rt overnight and concentrated. The residue was purified by chromatography to give the sub-title compound. Yield: 130 mg.

Workup

  1. concentrationconcentrated
  2. customThe residue was purified by chromatography

Sources & evidence

ORD record
ord-61544b6e73ea4961aed7993696c5fdf6
Source dataset
uspto-grants-2014_12
Patent number
US08921405B2

Reaction notes

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