Diisopropylcarbodiimide → HCID 46871734, compound

HRID 1410194Notes

Reaction equation

HRID 1410194 reaction equation
CC(N=C=NC(C)C)C.[C:10]([NH:13][CH:14]([C:16]1[CH:17]=[CH:18][C:19]([Cl:44])=[C:20]([NH:22][C:23](=S)[NH:24][C:25]2[CH:26]=[C:27]([CH:38]=[CH:39][C:40]=2[NH:41][CH3:42])[C:28]([NH:30][C:31]2[CH:36]=[CH:35][C:34]([Br:37])=[CH:33][CH:32]=2)=[O:29])[CH:21]=1)[CH3:15])(=[O:12])[CH3:11]>CN(C=O)C>[C:10]([NH:13][CH:14]([C:16]1[CH:17]=[CH:18][C:19]([Cl:44])=[C:20]([NH:22][C:23]2[N:41]([CH3:42])[C:40]3[CH:39]=[CH:38][C:27]([C:28]([NH:30][C:31]4[CH:36]=[CH:35][C:34]([Br:37])=[CH:33][CH:32]=4)=[O:29])=[CH:26][C:25]=3[N:24]=2)[CH:21]=1)[CH3:15])(=[O:12])[CH3:11]

Participants

4

Reactant 2

HCID 12734DiisopropylcarbodiimideHCID 59529808HCID 59529808, compound

Product 1

HCID 46871734HCID 46871734, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

N,N-Diisopropylcarbodiimide (46 L, 0.2 mmol) was added to 3-{3-[5-(1-acet-amidoethyl)-2-chlorophenyl]thioureido}-N-(4-bromophenyl)-4-(methylamino)benzamide (130 mg, 0.2 mmol) in DMF (2 mL) at rt. The mixture was stirred at 80° C. for 2 h, cooled and concentrated. The residue was purified by chromatography to give the title compound.

Workup

  1. temperaturecooled
  2. concentrationconcentrated
  3. customThe residue was purified by chromatography

Sources & evidence

ORD record
ord-701004dd933c4966be15f6e77b633e91
Source dataset
uspto-grants-2014_12
Patent number
US08921405B2

Reaction notes

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