Hydrochloric Acid → HCID 178468556, compound

HRID 1410196Notes

Reaction equation

HRID 1410196 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:30]=[CH:29][C:9]2[N:10]=[C:11]([NH:13][C:14]3[CH:19]=[C:18]([CH2:20][NH:21]C(C(C)(C)C)=O)[CH:17]=[CH:16][C:15]=3[Cl:28])[NH:12][C:8]=2[CH:7]=1)=[O:5])[CH3:2].[ClH:31]>O1CCOCC1>[CH2:1]([O:3][C:4]([C:6]1[C:30]([Cl:31])=[CH:29][C:9]2[N:10]=[C:11]([NH:13][C:14]3[CH:19]=[C:18]([CH2:20][NH2:21])[CH:17]=[CH:16][C:15]=3[Cl:28])[NH:12][C:8]=2[CH:7]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67135221HCID 67135221, compound

Product 1

HCID 178468556HCID 178468556, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 1.15 g (2.4 mmol) Ethyl-2-[5-(tert.butylcarbonylaminomethyl)-2-chlorophenylamino]-benzimidazole-5-carboxylate and 10 ml 4M HCl in Dioxane was stirred overnight. The reaction mixture was concentrated under reduced pressure to give the sub-title compound. Yield: 1.0 g (100%).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-f9eca117f140409abba8dbbb9193f09e
Source dataset
uspto-grants-2014_12
Patent number
US08921405B2

Reaction notes

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