反应详情

温度

90 °C

To a solution of 1-Bromo-4-chloro-5-(4-ethoxybenzyl)-2-methoxybenzene (6, 11.3 mmol) in N,N-dimethylformamide (50 mL) was added sodium ethane thiolate (3.17 g, 34 mmol) and heated at 90° C. for 3 h. The reaction mixture was cooled to 0° C., neutralized with 1N HCl, and the organic layer was separated and the aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with brine, dried over magnesium sulfate, filtered and concentrated in vacuo to yield the title compound as yellow oil which was used without further purification.

1. temperatureThe reaction mixture was cooled to 0° C.
2. customthe organic layer was separated
3. extractionthe aqueous layer was extracted with ethyl acetate
4. washThe combined organic layers were washed with brine
5. dry with materialdried over magnesium sulfate
6. filtrationfiltered
7. concentrationconcentrated in vacuo