Phenylhydrazine → HCID 85344752, compound

HRID 1410544Notes

Reaction equation

[C:1]1([NH:7][NH2:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O=[C:10]([CH3:17])[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13]>>[C:1]1([NH:7][N:8]=[C:10]([CH3:17])[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

Reactant 2

HCID 7516Phenylhydrazine

HCID 8868Ethyl Acetoacetate

Product 1

HCID 85344752HCID 85344752, compound

Conditions

Temperature: 0 °C

Procedure

To a solution of phenyl hydrazine (125 g, 1150 mmol) and ethyl 3-oxobutanoate (100 g, 770 mmol) in terbutyl dimethyl ether (1000 mL) acetic acid (2 mL) was added. The resulting mixture was stirred at 0° C. for 1 h. The solvent was evaporated under vacuum. The residue (220 g) was used as such for next step.

Workup

customThe solvent was evaporated under vacuum

Sources & evidence

ORD record: ord-16610cd459ce49f6a1f3c0df724df1ca
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08921560B2

Reaction notes

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