Acetate → 1'-(4-chlorophenyl)-6'-methoxy-5',7',8'-trimethyl-1'H-spiro[cyclobutane-1,3'-quinolin]-4'(2'H)-one

HRID 141108Notes

Reaction equation

HRID 141108 reaction equation
[CH3:1][O:2][c:3]1[c:4]([CH3:19])[c:5]2[c:13]([c:14]([CH3:17])[c:15]1[CH3:16])[NH:12][CH2:11][C:7]1([C:6]2=[O:18])[CH2:8][CH2:9][CH2:10]1.[CH3:37][CH2:38][O:39][C:40]([CH3:41])=[O:42].[CH3:43][CH2:44][CH2:45][CH2:46][CH2:47][CH3:48].[Cl:20][c:21]1[cH:22][cH:23][c:24]([I:27])[cH:25][cH:26]1.[O-:29][C:30]([CH3:31])=[O:32].[O-:33][C:34]([CH3:35])=[O:36].[Pd+2:28]>>[CH3:1][O:2][c:3]1[c:4]([CH3:19])[c:5]2[c:13]([c:14]([CH3:17])[c:15]1[CH3:16])[N:12]([c:24]1[cH:23][cH:22][c:21]([Cl:20])[cH:26][cH:25]1)[CH2:11][C:7]1([C:6]2=[O:18])[CH2:8][CH2:9][CH2:10]1

Participants

7

Reactant 6

HCID 175Acetate2×HCID 8058HexaneHCID 8857Ethyl AcetateHCID 125101-Chloro-4-iodobenzeneHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 690523766'-Methoxy-5',7',8'-trimethyl-1'H-spiro[cyclobutane-1,3'-quinolin]-4'(2'H)-one

Product 1

HCID 690567921'-(4-chlorophenyl)-6'-methoxy-5',7',8'-trimethyl-1'H-spiro[cyclobutane-1,3'-quinolin]-4'(2'H)-one

Sources & evidence

ORD record
ord-f57e60d85a62485c80e079c4d8c42206
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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