反应详情

温度

0 °C

To a solution of 3-fluoro-2-nitroaniline (2.1 g, 13.4 mmol) in DMF (30 mL) at 0° C. was added a solution of N-bromosuccinimide (2.4 g, 13.4 mmol) in DMF (20 mL). The resulting solution was stirred at 0° C. for 30 minutes and then warmed to room temperature over 1 hour. The solution was diluted with EtOAc, washed with H2O and brine, dried over MgSO4, filtered and concentrated to give the title compound (3.1 g, 97%).

1. temperaturewarmed to room temperature over 1 hour
2. washwashed with H2O and brine
3. dry with materialdried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated