Hydrochloric Acid → HCID 178438621, compound

HRID 1412295Notes

Reaction equation

HRID 1412295 reaction equation
C(OC(=O)[CH2:5][O:6][CH:7]1[CH2:12][CH2:11][CH:10]([N:13]2[C:18](=[O:19])[C:17]([CH2:20][C:21]3[CH:26]=[CH:25][C:24]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=4[C:33]#[N:34])=[CH:23][CH:22]=3)=[C:16]([CH2:35][CH2:36][CH3:37])[N:15]3[N:38]=[C:39]([CH3:41])[N:40]=[C:14]23)[CH2:9][CH2:8]1)C.C[Mg]Br.Cl>O1CCCC1>[OH:6][C:7]([CH3:12])([CH3:8])[CH2:5][O:6][C@H:7]1[CH2:8][CH2:9][C@H:10]([N:13]2[C:18](=[O:19])[C:17]([CH2:20][C:21]3[CH:22]=[CH:23][C:24]([C:27]4[C:28]([C:33]#[N:34])=[CH:29][CH:30]=[CH:31][CH:32]=4)=[CH:25][CH:26]=3)=[C:16]([CH2:35][CH2:36][CH3:37])[N:15]3[N:38]=[C:39]([CH3:41])[N:40]=[C:14]23)[CH2:11][CH2:12]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 86644030Ethyl[(4-{6-[(2'-cyanobiphenyl-4-yl)methyl]-2-methyl-5-oxo-7-propyl[1,2,4]triazolo[1,5-a]pyrimidin-4(5H)-yl}cyclohexyl)oxy]acetateHCID 178418573HCID 178418573, compound

Product 1

HCID 178438621HCID 178438621, compoundYield 131.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Ethyl[(4-{6-[(2′-cyanobiphenyl-4-yl)methyl]-2-methyl-5-oxo-7-propyl[1,2,4]triazolo[1,5-a]pyrimidin-4(5H)-yl}cyclohexyl)oxy]acetate (0.5 g) was dissolved in tetrahydrofuran (10 mL), and methylmagnesium bromide (1.0 M tetrahydrofuran solution, 4.2 mL) was added at 0° C. After stirring at the same temperature for 1 hr, 1 N hydrochloric acid was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The obtained ethyl acetate layer was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography to give the title compound as a colorless solid (0.32 g, 56%).

Workup

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe obtained ethyl acetate layer was washed with saturated brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was evaporated under reduced pressure
  5. customThe obtained residue was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-5a0029444ea041ec879a51cec3344d04
Source dataset
uspto-grants-2014_12
Patent number
US08921379B2

Reaction notes

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