Hydrochloric Acid → HCID 12878936, compound

HRID 1413040Notes

Reaction equation

HRID 1413040 reaction equation
[F:1][C:2]1[CH:14]=[CH:13][C:12]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5](=[O:15])[C:4]=2[C:3]=1[C:16]([O:18]CC)=[O:17].[OH-].[Na+].Cl>O>[F:1][C:2]1[CH:14]=[CH:13][C:12]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5](=[O:15])[C:4]=2[C:3]=1[C:16]([OH:18])=[O:17]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 12878935HCID 12878935, compound

Product 1

HCID 12878936HCID 12878936, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The ethyl 2-fluoro-fluoren-9-one-1-carboxylate is mixed with 500 ml of NaOH 6N and refluxed for 2 hours. After cooling, the mixture is diluted with twice its volume of water and acidified with concentrated HCl. The yellow precipitate that forms is filtered and washed with water. The melting point of the pure product isolated from column chromatography on silica gel (eluant: CHCl3 /CH3CO2C2H5 3/1) is: 209.210° C.

Workup

  1. temperaturerefluxed for 2 hours
  2. temperatureAfter cooling
  3. filtrationThe yellow precipitate that forms is filtered
  4. washwashed with water
  5. customThe melting point of the pure product isolated from column chromatography on silica gel (eluant: CHCl3 /CH3CO2C2H5 3/1)
  6. custom209.210° C.

Sources & evidence

ORD record
ord-6a9cc0c7ccba443cb25c3bde471454f7
Source dataset
uspto-grants-1981_02
Patent number
US04248622

Reaction notes

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