反应详情

Sodium metal (4.1 g) was dissolved in absolute ethanol (90 ml) and formamidine acetate (18.4 g) and 2-(p-methoxyphenoxy)-3-(dimethylamino)acrolein (13.0 g) were added to the ethanolic solution of sodium ethoxide. The mixture was heated under reflux, with stirring, for 40 hr and then the solvent was removed, by distillation under reduced pressure. The residue was treated with water (200 ml) and chloroform (200 ml), the chloroform layer was separated and the chloroform removed by distillation under reduced pressure. The residue was purified by column chromatography over silica gel using chloroform as eluent to give 5-(p-methoxyphenoxy)pyrimidine as an oil (7.7 g) which was characterised by p.m.r. spectroscopy.

1. temperatureThe mixture was heated
2. temperatureunder reflux
3. customthe solvent was removed, by distillation under reduced pressure
4. additionThe residue was treated with water (200 ml) and chloroform (200 ml)
5. customthe chloroform layer was separated
6. customthe chloroform removed by distillation under reduced pressure
7. customThe residue was purified by column chromatography over silica gel