Potassium Carbonate → HCID 54204017, compound

HRID 1413073Notes

Reaction equation

HRID 1413073 reaction equation
[C:1]([C:3]1[C:12]2[O:11][CH2:10][CH2:9][O:8][C:7]=2[C:6]([OH:13])=[CH:5][CH:4]=1)#[N:2].[CH2:14]([CH:16]1[O:18][CH2:17]1)Br.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([O:13][CH2:14][CH:16]2[O:18][CH2:17]2)=[C:7]2[O:8][CH2:9][CH2:10][O:11][C:12]=12)#[N:2]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 18430EpibromohydrinHCID 54260250HCID 54260250, compound

Product 1

HCID 54204017HCID 54204017, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 31 g of 5-cyano-8-hydroxy-1,4-benzodioxane (VII) (Code number 770583), 38.35 g of epibromohydrin and 133 g of potassium carbonate in 300 ml of acetonitrile was brought to reflux for 12 hours. The mixture was filtered, the product then crystallized in the filtrate, it was filtered out and recrystallized in acetonitrile.

Workup

  1. temperatureto reflux for 12 hours
  2. filtrationThe mixture was filtered
  3. customthe product then crystallized in the filtrate, it
  4. filtrationwas filtered out
  5. customrecrystallized in acetonitrile

Sources & evidence

ORD record
ord-f7393267758e4932bf647a6d2e1a9f1e
Source dataset
uspto-grants-1981_02
Patent number
US04248788

Reaction notes

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