Benzyl Chloride → HCID 53743283, compound

HRID 1413076Notes

Reaction equation

HRID 1413076 reaction equation
O[C:2]1[C:11]2[O:10][CH2:9][CH2:8][O:7][C:6]=2[C:5]([C:12](=[O:14])[CH3:13])=[CH:4][CH:3]=1.[CH2:15](Cl)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.C(=O)([O-])[O-:24].[K+].[K+]>>[CH2:15]([O:24][CH:8]1[O:7][C:6]2[C:5]([C:12](=[O:14])[CH3:13])=[CH:4][CH:3]=[CH:2][C:11]=2[O:10][CH2:9]1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 3

HCID 7503Benzyl ChlorideHCID 11430Potassium CarbonateHCID 803371-(2,3-Dihydro-8-hydroxy-1,4-benzodioxin-5-yl)ethan-1-one

Product 1

HCID 53743283HCID 53743283, compoundYield 95%

Procedure

A suspension of 97 g (0.5 mole) of 5 hydroxy-8-acetyl-1,4-benzodioxane (VIIi), of 127 g (1 mole) of benzyl chloride and 155 g (1.12 mole) of potassium carbonate in 150 ml of absolute alcohol was brought to reflux for 24 hours. After filtration the solvent was evaporated, the residue was taken up in chloroform, washed with a solution of soda (NaOH) 1 N, the solvent was evaporated and the product was crystallized in alcohol, 135 g of product expected were obtained.

Workup

  1. temperatureto reflux for 24 hours
  2. filtrationAfter filtration the solvent
  3. customwas evaporated
  4. washwashed with a solution of soda (NaOH) 1 N
  5. customthe solvent was evaporated
  6. customthe product was crystallized in alcohol

Sources & evidence

ORD record
ord-5bcccd7e9b1e41e79eac8333140f4d50
Source dataset
uspto-grants-1981_02
Patent number
US04248788

Reaction notes

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