Sodium → HCID 20291497, compound

HRID 1413314Notes

Reaction equation

HRID 1413314 reaction equation
[CH3:1][O:2][C:3]([CH:5]1[NH:10][CH2:9][CH:8]2[CH:6]1[CH2:7]2)=[O:4].[Na]>CO>[CH3:1][O:2][C:3]([C:5]1[CH:6]2[CH:8]([CH2:9][N:10]=1)[CH2:7]2)=[O:4]

Participants

4

Reactant 2

HCID 5360545SodiumHCID 20060492Methyl 3-azabicyclo[3.1.0]hexane-2-carboxylate

Product 1

HCID 20291497HCID 20291497, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

By a method analogous to that of Example 1, this compound was prepared from 2-methoxycarbonyl-3-azabicyclo(3.1.0)hexane. Sodium dissolved in methanol instead of ethanol was used as dehydrohalogenating agent. The desired compound was obtained as a straw-colored liquid in 70% yield. Its identity was confirmed by elemental analysis, and by NMR and IR analyses.

Sources & evidence

ORD record
ord-2ef7b3e230ff478098242edcbad0d9f5
Source dataset
uspto-grants-1981_02
Patent number
US04249936

Reaction notes

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