Bromoacetyl bromide → HCID 20291819, compound

HRID 1413361Notes

Reaction equation

HRID 1413361 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH3:23])[C:5]2[N:11]=[C:10]([NH:12][NH2:13])[CH2:9][N:8]=[C:7]([C:14]3[CH:19]=[CH:18][C:17]([S:20][CH3:21])=[CH:16][CH:15]=3)[C:6]=2[CH:22]=1.[Br:24][CH2:25][C:26](Br)=O.C([O-])(=O)C.[Na+]>>[CH3:1][C:2]1[CH:3]=[C:4]([CH3:23])[C:5]2[N:11]3[C:26]([CH2:25][Br:24])=[N:13][N:12]=[C:10]3[CH2:9][N:8]=[C:7]([C:14]3[CH:15]=[CH:16][C:17]([S:20][CH3:21])=[CH:18][CH:19]=3)[C:6]=2[CH:22]=1

Participants

4

Reactant 3

HCID 61147Bromoacetyl bromideHCID 517045Sodium AcetateHCID 20291821HCID 20291821, compound

Product 1

HCID 20291819HCID 20291819, compound

Procedure

In the manner given in Preparation 2, 7,9-dimethyl-5-[p-(methylthio)phenyl]-3H-1,4-benzodiazepin-2-yl hydrazine was reacted with bromoacetyl bromide and after 1.5 hours with sodium acetate, than the mixture was refluxed to give 8,10-dimethyl-1-(bromomethyl)-6-[p-(methylthio)phenyl]-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Workup

  1. temperaturewas refluxed

Sources & evidence

ORD record
ord-244bab1c77d24dbeb3959f4f5893eeeb
Source dataset
uspto-grants-1981_02
Patent number
US04250094

Reaction notes

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