Sodium Iodide → HCID 20291840, compound

HRID 1413371Notes

Reaction equation

HRID 1413371 reaction equation
Cl[CH2:2][C:3]1[N:7]2[C:8]3[CH:23]=[CH:22][CH:21]=[CH:20][C:9]=3[C:10]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[Cl:19])=[N:11][CH2:12][C:6]2=[N:5][N:4]=1.[CH2:24]([NH:26][CH2:27][CH3:28])[CH3:25].[I-].[Na+]>>[CH2:24]([N:26]([CH2:2][C:3]1[N:7]2[C:8]3[CH:23]=[CH:22][CH:21]=[CH:20][C:9]=3[C:10]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[Cl:19])=[N:11][CH2:12][C:6]2=[N:5][N:4]=1)[CH2:27][CH3:28])[CH3:25]

Participants

4

Reactant 3

HCID 5238Sodium IodideHCID 8021DiethylamineHCID 12612349HCID 12612349, compound

Product 1

HCID 20291840HCID 20291840, compound

Procedure

In the manner given in Example 1, 1-(chloromethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]-benzodiazepine was reacted with diethylamine in the presence of sodium iodide to give 1-[(diethylamino)methyl]-6-(o-chlorophenyl)4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-3e5b381788e544b08f942fbe137fc9e3
Source dataset
uspto-grants-1981_02
Patent number
US04250094

Reaction notes

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