Sodium Iodide → HCID 20291830, compound

HRID 1413373Notes

Reaction equation

[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH2:15]Br)=[N:13][N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[F:23])[C:6]=2[CH:24]=1.[CH2:25]([NH:27][CH2:28][CH3:29])[CH3:26].[I-].[Na+]>>[CH2:25]([N:27]([CH2:15][C:12]1[N:11]2[C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:24][C:6]=3[C:7]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[F:23])=[N:8][CH2:9][C:10]2=[N:14][N:13]=1)[CH2:28][CH3:29])[CH3:26]

Participants

Reactant 3

HCID 5238Sodium Iodide

HCID 8021Diethylamine

HCID 20291839HCID 20291839, compound

Product 1

HCID 20291830HCID 20291830, compound

Procedure

In the manner given in Example 1, 8-fluoro-1-(bromomethyl)-6-(o-fluorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine was reacted with diethylamine in the presence of sodium iodide to give 1-[(diethylamino)methyl]-8-fluoro-6-(o-fluorophenyl)-4H-s-triazolo-[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record: ord-2bdde4e7e7f444b1a43b95719bda593b
Source dataset: uspto-grants-1981_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04250094

Reaction notes

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