Sodium Iodide → HCID 20291851, compound

HRID 1413377Notes

Reaction equation

HRID 1413377 reaction equation
[C:1]([C:3]1[C:8]2[C:9]([C:20]3[CH:25]=[CH:24][C:23]([Br:26])=[CH:22][CH:21]=3)=[N:10][CH2:11][C:12]3[N:13]([C:14]([CH:17](Br)[CH3:18])=[N:15][N:16]=3)[C:7]=2[CH:6]=[CH:5][C:4]=1[C:27]#[N:28])#[N:2].[CH2:29]([NH:31][CH2:32][CH3:33])[CH3:30].[I-].[Na+]>>[C:1]([C:3]1[C:8]2[C:9]([C:20]3[CH:25]=[CH:24][C:23]([Br:26])=[CH:22][CH:21]=3)=[N:10][CH2:11][C:12]3[N:13]([C:14]([CH:17]([N:31]([CH2:32][CH3:33])[CH2:29][CH3:30])[CH3:18])=[N:15][N:16]=3)[C:7]=2[CH:6]=[CH:5][C:4]=1[C:27]#[N:28])#[N:2]

Participants

4

Reactant 3

HCID 5238Sodium IodideHCID 8021DiethylamineHCID 20291817HCID 20291817, compound

Product 1

HCID 20291851HCID 20291851, compound

Procedure

In the manner given in Example 1, 7,8-dicyano-1-(α-bromoethyl)-6-(p-bromophenyl)-4H-s-triazolo[4,3-a][1,4]-benzodiazepine was reacted with diethylamine in the presence of sodium iodide to give 7,8-dicyano-1-[α-(diethylamino)ethyl]-6-(p-bromophenyl)-4H-s-triazolo[4,3-a][1,4]-benzodiazepine.

Sources & evidence

ORD record
ord-8aaa4d48bc134f13a655c7b628560510
Source dataset
uspto-grants-1981_02
Patent number
US04250094

Reaction notes

Loading…