Hydrochloric Acid → 2-(cyclopropylamino)acetic acid hydrochloride(WX191407S1)

HRID 1413414Notes

Reaction equation

HRID 1413414 reaction equation
[CH:1]1([NH:4][CH2:5][C:6]([O:8]CC)=[O:7])[CH2:3][CH2:2]1.[ClH:11]>O>[ClH:11].[CH:1]1([NH:4][CH2:5][C:6]([OH:8])=[O:7])[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22476174Glycine, N-cyclopropyl-, ethyl ester

Product 1

HCID 438108222-(cyclopropylamino)acetic acid hydrochloride(WX191407S1)

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Ethyl cyclopropylaminoacetate was stirred in a mixture of concentrated hydrochloric acid and water until the reaction had subsided. The mixture was then heated to reflux for 2 hours. The resulting solution was evaporated to give a white solid which was triturated with acetone and recrystallised from methanol/ethyl acetate to give cyclopropylaminoacetic acid hydrochloride of melting point 189°-191° C. (decomposition).

Workup

  1. temperatureThe mixture was then heated
  2. temperatureto reflux for 2 hours
  3. customThe resulting solution was evaporated
  4. customto give a white solid which
  5. customwas triturated with acetone
  6. customrecrystallised from methanol/ethyl acetate

Sources & evidence

ORD record
ord-a8b5b874a0d840b3935fdf5af68ec143
Source dataset
uspto-grants-1981_02
Patent number
US04250085

Reaction notes

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