反应详情

温度

0 °C

7.5 ml of triethylamine were slowly introduced into 300 ml of phosphorous oxychloride cooled to 0° C., then were added 30 g of 5-ethoxycarbonyl 4-hydroxy 2-ethyl pyrimidine (VII) prepared in the preceding stage and the suspension was brought up to 40° C. under nitrogen scavenging. After dissolution, the phosphorous oxychloride was evaporated and the residue diluted in a mixture of water and chloroform. This was decanted, the chloroform phase was twice washed with water, dried on sodium sulfate and the solvent evaporated. The raw product obtained, after checking the purity by thin layer chromatography, was reacted in the following stage 3.

1. customprepared in the preceding stage
2. customwas brought up to 40° C. under nitrogen scavenging
3. dissolutionAfter dissolution
4. customthe phosphorous oxychloride was evaporated
5. additionthe residue diluted in a mixture of water and chloroform
6. customThis was decanted
7. washthe chloroform phase was twice washed with water
8. customdried on sodium sulfate
9. customthe solvent evaporated