反应详情

A mixture of the product of Step A (2.0 g; 7.03 mmoles) and propargylamine (3.44 g; 62.5 mmoles) in acetonitrile (30 ml) was stirred and heated to reflux temperature under a positive pressure of nitrogen for 1.5 hours then stirred at ambient temperature for 42 hours. The reaction mixture was filtered and the product collected. Recrystallization from acetonitrile gave the title compound; mp 147°-148°.

1. temperatureheated
2. temperatureto reflux temperature under a positive pressure of nitrogen for 1.5 hours
3. stirringthen stirred at ambient temperature for 42 hours
4. filtrationThe reaction mixture was filtered
5. customthe product collected
6. customRecrystallization from acetonitrile