Propargylamine → HCID 70570126, compound

HRID 1413552Notes

Reaction equation

HRID 1413552 reaction equation
[N+:1]([CH:4]=[C:5](SC)[NH:6][CH2:7][CH2:8][S:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1)([O-:3])=[O:2].[CH2:19]([NH2:22])[C:20]#[CH:21]>C(#N)C>[N+:1]([CH:4]=[C:5]([NH:22][C:19]#[C:20][CH3:21])[NH:6][CH2:7][CH2:8][S:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 239041PropargylamineHCID 705703291-Nitro-2-methylthio-2-[2-(2-pyridylmethylthio)ethylamino]ethylene

Product 1

HCID 70570126HCID 70570126, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of the product of Step A (2.0 g; 7.03 mmoles) and propargylamine (3.44 g; 62.5 mmoles) in acetonitrile (30 ml) was stirred and heated to reflux temperature under a positive pressure of nitrogen for 1.5 hours then stirred at ambient temperature for 42 hours. The reaction mixture was filtered and the product collected. Recrystallization from acetonitrile gave the title compound; mp 147°-148°.

Workup

  1. temperatureheated
  2. temperatureto reflux temperature under a positive pressure of nitrogen for 1.5 hours
  3. stirringthen stirred at ambient temperature for 42 hours
  4. filtrationThe reaction mixture was filtered
  5. customthe product collected
  6. customRecrystallization from acetonitrile

Sources & evidence

ORD record
ord-6b26959808754933adba1ad524efa929
Source dataset
uspto-grants-1981_02
Patent number
US04250316

Reaction notes

Loading…