Tert-Butylamine → 3-Isopropyl-5-[2-(2-hydroxy-3-tert.-butylaminopropoxy)-styryl]-isoxazole

HRID 1413848Notes

Reaction equation

HRID 1413848 reaction equation
[CH:1]([C:4]1[CH:8]=[C:7]([CH:9]=[CH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[O:17][CH2:18][CH:19]2[O:21][CH2:20]2)[O:6][N:5]=1)([CH3:3])[CH3:2].[C:22]([NH2:26])([CH3:25])([CH3:24])[CH3:23]>>[CH:1]([C:4]1[CH:8]=[C:7]([CH:9]=[CH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[O:17][CH2:18][CH:19]([OH:21])[CH2:20][NH:26][C:22]([CH3:25])([CH3:24])[CH3:23])[O:6][N:5]=1)([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 6385Tert-ButylamineHCID 544590543-Isopropyl-5-[2-(2,3-epoxypropoxy)-styryl]-isoxazole

Product 1

HCID 566339793-Isopropyl-5-[2-(2-hydroxy-3-tert.-butylaminopropoxy)-styryl]-isoxazole

Procedure

7 g (0.025 mole) of 3-isopropyl-5-[2-(2,3-epoxypropoxy)-styryl]-isoxazole and 3.6 g (0.05 mole) of tert.-butylamine are reacted by the method described in Example 4. 5.8 g (59% of theory) of colorless crystals are obtained. Melting point 191°-193° C.

Workup

  1. custom5.8 g (59% of theory) of colorless crystals are obtained

Sources & evidence

ORD record
ord-bed7e878abab43dc9134aba95af53974
Source dataset
uspto-grants-1981_02
Patent number
US04251539

Reaction notes

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