Tert-Butylamine → 3-tert.-Butyl-5-[2-(2-hydroxy-3-tert.-butylaminopropoxy)-styryl]-isoxazole

HRID 1413850Notes

Reaction equation

HRID 1413850 reaction equation
[C:1]([C:5]1[CH:9]=[C:8]([CH:10]=[CH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[O:18][CH2:19][CH:20]2[O:22][CH2:21]2)[O:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2].[C:23]([NH2:27])([CH3:26])([CH3:25])[CH3:24]>>[C:1]([C:5]1[CH:9]=[C:8]([CH:10]=[CH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[O:18][CH2:19][CH:20]([OH:22])[CH2:21][NH:27][C:23]([CH3:26])([CH3:25])[CH3:24])[O:7][N:6]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 6385Tert-ButylamineHCID 566288773-Tert.-butyl-5-[2-(2,3-epoxypropoxy)-styryl]-isoxazole

Product 1

HCID 566253853-tert.-Butyl-5-[2-(2-hydroxy-3-tert.-butylaminopropoxy)-styryl]-isoxazole

Procedure

7 g (0.023 mole) of 3-tert.-butyl-5-[2-(2,3-epoxypropoxy)-styryl]-isoxazole and 3.4 g (0.047 mole) of tert.-butylamine are reacted by the method described in Example 4. 6.8 g (72% of theory) of colorless crystals are obtained. Melting point 207°-208° C.

Workup

  1. custom6.8 g (72% of theory) of colorless crystals are obtained

Sources & evidence

ORD record
ord-20713af56de94e78a653061e3e8e0492
Source dataset
uspto-grants-1981_02
Patent number
US04251539

Reaction notes

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