4-Bromophenol → HCID 20291093, compound

HRID 1413853Notes

Reaction equation

HRID 1413853 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([CH:9](O)[CH3:10])[CH:3]=1.[Br:12][C:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=1>Cl>[Br:12][C:13]1[CH:14]=[CH:15][C:16]([OH:19])=[C:17]([CH:9]([C:4]2[CH:3]=[C:2]([Cl:1])[CH:7]=[CH:6][C:5]=2[OH:8])[CH3:10])[CH:18]=1

Participants

4

Reactant 2

HCID 78084-BromophenolHCID 13721957HCID 13721957, compound

Product 1

HCID 20291093HCID 20291093, compoundYield 43.5%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidCatalyst

Procedure

4-Chloro-2-(1-hydroxyethyl)phenol (4 g) was added slowly to a melt of 4-bromophenol (7.9 g) and concentrated hydrochloric acid (3 drops) at 100° C. The melt was heated at this temperature for 3 hr and then cooled and the product crystallised from benzene/hexane to give 1-(5-bromo-2-hydroxyphenyl)-1-(5-chloro-2-hydroxyphenyl)ethane (3.3 g); m.p. 167° C.

Workup

  1. temperatureThe melt was heated at this temperature for 3 hr
  2. temperaturecooled
  3. customthe product crystallised from benzene/hexane

Sources & evidence

ORD record
ord-07815acb115e48439cbb499e2cfe61e2
Source dataset
uspto-grants-1981_02
Patent number
US04251546

Reaction notes

Loading…