4-Morpholinecarbonyl chloride → 4-Morpholinecarboxylic acid, 3,4,5-trimethoxyphenyl ester

HRID 1414002Notes

Reaction equation

HRID 1414002 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([O-:13])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[Na+].Cl[C:16]([N:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1)=[O:17]>CN(C)C=O>[CH3:12][O:11][C:7]1[CH:6]=[C:5]([CH:4]=[C:3]([O:2][CH3:1])[C:8]=1[O:9][CH3:10])[O:13][C:16]([N:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1)=[O:17]

Participants

4

Reactant 2

HCID 848104-Morpholinecarbonyl chlorideHCID 23684108HCID 23684108, compound

Product 1

HCID 30518774-Morpholinecarboxylic acid, 3,4,5-trimethoxyphenyl ester

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 10.15 g (0.049 mole) sodium 3,4,5-trimethoxyphenolate in 100 ml anhydrous dimethylformamide are added gradually, with stirring, 7.5 g (0.050 mole) N-chloroformyl-morpholine.

Sources & evidence

ORD record
ord-d85994d77e7943158d246cdec90a3226
Source dataset
uspto-grants-1981_02
Patent number
US04252804

Reaction notes

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