Hydrochloric Acid → Pteridine-2,4,7-triamine, 6-(4-(2-(dimethylamino)ethoxy)phenyl)-

HRID 1414013Notes

Reaction equation

HRID 1414013 reaction equation
[Na].[CH3:2][N:3]([CH3:16])[CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14]#[N:15])=[CH:9][CH:8]=1.Cl.[NH2:18][C:19]1[N:24]=[C:23]([NH2:25])[C:22]([N:26]=O)=[C:21]([NH2:28])[N:20]=1>C(OCCO)C>[NH2:18][C:19]1[N:24]=[C:23]([NH2:25])[C:22]2[C:21](=[N:28][C:14]([NH2:15])=[C:13]([C:10]3[CH:9]=[CH:8][C:7]([O:6][CH2:5][CH2:4][N:3]([CH3:16])[CH3:2])=[CH:12][CH:11]=3)[N:26]=2)[N:20]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 705045-Nitroso-2,4,6-pyrimidinetriamineHCID 5360545SodiumHCID 13340495HCID 13340495, compound

Product 1

HCID 3056902Pteridine-2,4,7-triamine, 6-(4-(2-(dimethylamino)ethoxy)phenyl)-

Reagents, catalysts & solvents 1

HCID 8076Glycol monoethyl etherSolvent

Procedure

0.03 mol of metallic sodium is dissolved with stirring in 150 ml of 2-ethoxyethanol. 3.1 g (0.013 mol) of 4-(β-dimethylamino-ethoxy)-phenyl acetonitrile in the form of the hydrochloride are added with stirring followed by 1.45 g (0.01 mol) of 2,4,6-triamino-5-nitroso-pyrimidine. After stirring for 48 hours at 60°-65° C. excluding access of moisture, the mixture is centrifuged when still hot. Petroleum ether is added to the solution obtained until it becomes cloudy. The solution is kept refrigerated to complete precipitation. The precipitate is filtered off. It can be recrystallized from n-butanol.

Workup

  1. stirringAfter stirring for 48 hours at 60°-65° C.
  2. customobtained until it
  3. customprecipitation
  4. filtrationThe precipitate is filtered off
  5. customIt can be recrystallized from n-butanol

Sources & evidence

ORD record
ord-8dec58b0fb674f2697f09ab6720b8aa1
Source dataset
uspto-grants-1981_02
Patent number
US04252809

Reaction notes

Loading…