反应详情

2,3-Epoxy-1-[(1-phenyl-5-tetrazolyl)oxy]propane (43.7 g., 0.20 mole) was heated at the reflux temperature in 150 ml. of tert.-butylamine and 300 ml. of benzene for 9 hours. The solvents were evaporated in vacuo and the residual oil was dissolved in 100 ml. of EtOH and acidified with ethanolic HCl. Dilution with diethyl ether gave 44.8 g. of the hydrochloride of the product, m.p. 73°-82°. Recrystallization from i-PrOH-IPE gave 30.8 g., m.p. 152.5°-154.5° (corr.).

1. customThe solvents were evaporated in vacuo
2. dissolutionthe residual oil was dissolved in 100 ml
3. customDilution with diethyl ether gave 44.8 g
4. customRecrystallization from i-PrOH-IPE
5. customgave 30.8 g