Hydrogen Bromide → HCID 86737516, compound

HRID 1414065Notes

Reaction equation

HRID 1414065 reaction equation
[BrH:1].[CH3:2][O:3][C@@H:4]1[CH2:9][CH2:8][CH2:7][NH:6][C@H:5]1[CH2:10][C:11](=[O:13])[CH3:12].Br>C(O)(=O)C>[BrH:1].[Br:1][CH2:12][C:11](=[O:13])[CH2:10][C@H:5]1[C@H:4]([O:3][CH3:2])[CH2:9][CH2:8][CH2:7][NH:6]1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 86737518HCID 86737518, compound

Product 1

HCID 86737516HCID 86737516, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Using the procedure of U.S. Pat. No. 2,775,597, the product of Step A4 was reacted with a solution of 15% hydrogen bromide in acetic acid for 2 hours at room temperature and the mixture was evaporated to dryness under reduced pressure to obtain dextrorotary trans 3-bromo-1-(3-methoxy-2-piperidyl)-2-propanone hydrobromide melting at 143° C. and having a specific rotation [α]D20 =+25° (c=1% in methanol).

Workup

  1. customthe mixture was evaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-f85d5ccdaeb14e68957f8cdb650d8f13
Source dataset
uspto-grants-1981_02
Patent number
US04252947

Reaction notes

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