Phosphorus trichloride → HCID 6320223, compound

HRID 1414079Notes

Reaction equation

HRID 1414079 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[Br:12])[N+:8]([O-])=[C:7]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:6](=[O:19])[NH:5]2.P(Cl)(Cl)Cl>C1COCC1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[Br:12])[N:8]=[C:7]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:6](=[O:19])[NH:5]2

Participants

4

Reactant 2

HCID 24387Phosphorus trichlorideHCID 13055390HCID 13055390, compound

Product 1

HCID 6320223HCID 6320223, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

One gram of ethyl 6-chloro-7-bromo-3,4-dihydro-3-oxo-2-quinoxaline carboxylate N-oxide was dissolved in 50 ml. of THF. Six ml. of phosphorus trichloride were added and the resulting mixture heated gently at refluxing temperature overnight. The reaction mixture was poured into 500 ml. of an ice-water mixture. A solid, comprising ethyl 6-chloro-7-bromo-3,4-dihydro-3-oxo-2-quinoxaline carboxylate formed in the above reaction, was separated by filtration; melting point=203°-205° C.; yield=0.6 g.

Workup

  1. temperaturethe resulting mixture heated gently
  2. temperatureat refluxing temperature overnight
  3. additionThe reaction mixture was poured into 500 ml

Sources & evidence

ORD record
ord-c20e91ba57e14715877ad7c00aeaca08
Source dataset
uspto-grants-1981_02
Patent number
US04252954

Reaction notes

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