2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline → HCID 21486847, compound

HRID 1414239Notes

Reaction equation

HRID 1414239 reaction equation
[CH2:1]([S:3][C:4]1[O:8][C:7]([C:9]([Cl:11])=[O:10])=[N:6][N:5]=1)[CH3:2].[NH2:12][C:13]1[C:22]2[C:17](=[CH:18][C:19]([O:25][CH3:26])=[C:20]([O:23][CH3:24])[CH:21]=2)[N:16]=[C:15]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)[N:14]=1>>[ClH:11].[NH2:12][C:13]1[C:22]2[C:17](=[CH:18][C:19]([O:25][CH3:26])=[C:20]([O:23][CH3:24])[CH:21]=2)[N:16]=[C:15]([N:27]2[CH2:32][CH2:31][N:30]([C:9]([C:7]3[O:8][C:4]([S:3][CH2:1][CH3:2])=[N:5][N:6]=3)=[O:10])[CH2:29][CH2:28]2)[N:14]=1

Participants

3

Reactant 2

HCID 6162672-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazolineHCID 211840515-(Ethylsulfanyl)-1,3,4-oxadiazole-2-carbonyl chloride

Product 1

HCID 21486847HCID 21486847, compound

Procedure

The title compound was prepared from 5-ethylthio-1,3,4-oxadiazole-2-carbonyl chloride (0.79 g., 4.1 mmole) and 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline (1.19 g., 4.1 mmole) following the procedure described in Example 1. The product had a M.P. of 246°-248.5° C.

Sources & evidence

ORD record
ord-a916eddcf97448a783b141be7a20837e
Source dataset
uspto-grants-1977_01
Patent number
US04001238

Reaction notes

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