反应详情

To a stirred solution of 10.4 g of 3-(4-fluorobenzoyl)propionic acid and 6.0 g of triethylamine in 120 ml of tetrahydrofuran was added dropwise 6.0 g of ethyl chloroformate at a temperature below 0° C. After stirring was continued for half an hour, to the mixture was added a solution of 9.6 g of 2-(2-ethoxyphenoxy)ethylamine in 10 ml of tetrahydrofuran. Further stirring was continued at room temperature for 4 hours. The reaction mixture was filtered and the filtrate was concentrated to a residue under reduced pressure. The residue was recrystallized from benzene-hexane to give N-[2-(2-ethoxyphenoxy)ethyl]-3-(4-fluorobenzoyl)-propionamide melting at 98° - 100° C.

1. waitwas continued for half an hour, to the mixture
2. stirringFurther stirring
3. filtrationThe reaction mixture was filtered
4. concentrationthe filtrate was concentrated to a residue under reduced pressure
5. customThe residue was recrystallized from benzene-hexane