Trifluoroacetic acid → 3-Acetyl-1-methylpyrrole

HRID 1414738Notes

Reaction equation

HRID 1414738 reaction equation
C([C:4]1[N:5]([CH3:9])[CH:6]=[CH:7][CH:8]=1)(=O)C.F[C:11](F)(F)[C:12](O)=[O:13]>>[C:12]([C:7]1[CH:8]=[CH:4][N:5]([CH3:9])[CH:6]=1)(=[O:13])[CH3:11]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 612402-Acetyl-1-methylpyrrole

Product 1

HCID 5230573-Acetyl-1-methylpyrrole

Procedure

A solution of 3.0g of 2-acetyl-1-methylpyrrole in 30 ml of trifluoroacetic acid is heated under reflux for 90 minutes. The solvent is then evaporated in vacuo and the residue is partitioned between chloroform and sodium bicarbonate solution. The chloroform layer is dried and the solvent evaporated in vacuo to give 3-acetyl-1-methylpyrrole as a brown oil.

Workup

  1. temperatureunder reflux for 90 minutes
  2. customThe solvent is then evaporated in vacuo
  3. customthe residue is partitioned between chloroform and sodium bicarbonate solution
  4. dry with materialThe chloroform layer is dried
  5. customthe solvent evaporated in vacuo

Sources & evidence

ORD record
ord-51ba8b3305814f219d753510c037a1d5
Source dataset
uspto-grants-1977_01
Patent number
US04002643

Reaction notes

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