反应详情

To a warmed benzene solution of 1-(2-thiazolin-2-yl)-indolin-2-one (2.0 g, 7.2 mmol) and p-methoxybenzaldehyde (1.5 g, 11 mmole) is added piperidine (0.6 ml). The mixture is heated at reflux temperature for 2 hours. The reaction mixture is then washed with NaHSO3 solution, diluted HCl and water. The organic phase is dried over anhydrous MgSO4 and concentrated in vacuo. The residue is recrystallized once each from acetone/hexane, acetonitrile and CHCl3 /methanol and gives 1.3 g (43%) of the product (m.p. 164.5°-167° C, softens at 149° C).

1. temperatureThe mixture is heated
2. temperatureat reflux temperature for 2 hours
3. washThe reaction mixture is then washed with NaHSO3 solution, diluted HCl and water
4. dry with materialThe organic phase is dried over anhydrous MgSO4
5. concentrationconcentrated in vacuo
6. customThe residue is recrystallized once each from acetone/hexane, acetonitrile and CHCl3 /methanol