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HRID1415012

反应详情

EQUATION

反应方程式

HRID 1415012 的结构方程式

REACTANTS

反应物

2
结构：CCCCCCCCCC(=O)Cl
HCID66982

Decanoyl chloride

C10H19ClO

结构：CC[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@H]43)[C@@H]1CC[C@@H]2O
HCID10039774

Gon-4-en-3-one, 13-ethyl-17-hydroxy-, (17β)-(±)-

C19H28O2

PRODUCTS

生成物

1
结构：CCCCCCCCCC(=O)O[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@]12CC
HCID44626081

未命名化合物

收率 50.1%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：Cl
溶剂HCID313

Hydrochloric Acid

ClH

结构：c1ccncc1
溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

Add decanoyl chloride (1.9 g.) to 13β-ethyl-17β-hydroxy-gon-4-en-3-one (1.3 g.) in pyridine (12.5 cc.) and allow the mixture to stand at room temperature overnight. Pour the mixture in 2N hydrochloric acid and extract with ether. Wash, dry and evaporate the extracts and recrystallize the residue from benzene-hexane to give the title compound (1.0 g.), m.p. 97°-97.5°; ultraviolet absorption peak at 239 mμ (ε16,500); infrared absorption peaks at 5.74, 5.99, 6.17 μ.

WORKUP

后处理

  1. extractionextract with ether
  2. washWash
  3. customdry
  4. customevaporate the extracts
  5. customrecrystallize the residue from benzene-hexane