Hydrochloric Acid → HCID 86734423, compound

HRID 1415175Notes

Reaction equation

HRID 1415175 reaction equation
ClC1C=CC=CC=1C(C1C=CC(F)=CC=1)O[CH2:6][CH2:7][NH:8]C(=O)C.FC1C=CC(C(C2C=CC(F)=CC=2)OCCNC(=O)C)=CC=1.[C:45]([OH:52])(=[O:51])/[CH:46]=[CH:47]\[C:48]([OH:50])=[O:49].Cl>>[C:45]([OH:52])(=[O:51])/[CH:46]=[CH:47]\[C:48]([OH:50])=[O:49].[CH2:7]([NH2:8])[CH3:6]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 444266Maleic AcidHCID 21411013HCID 21411013, compoundHCID 21411018HCID 21411018, compound

Product 1

HCID 86734423HCID 86734423, compound

Procedure

Using the procedure described in Example IV but substituting an equivalent amount of N-{-2-[0-chloro-α-(p-fluorophenyl)benzyloxy]ethyl}acetamide for the N-{2-[bis(p-fluorophenyl)methoxy]ethyl}acetamide and maleic acid for the hydrogen chloride, there is obtained 2-[ 0 -chloro-α-(p-fluorophenyl)benzyloxy]ethylamine hydrogen maleate, which is crystallised from ethanol. Its melting point is 123°-123.5° C.

Sources & evidence

ORD record
ord-6a9881b8386d4d3b9ad38d55d912f134
Source dataset
uspto-grants-1977_01
Patent number
US04003932

Reaction notes

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