Methanol → HCID 57125898, compound

HRID 1415425Notes

Reaction equation

[CH:1]1([C:4](=O)[CH:5]=[CH:6][C:7]2[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=2)[CH2:3][CH2:2]1.[N+:15]([CH2:18][CH3:19])([O-:17])=[O:16].[Na].C[OH:22]>>[CH:1]1([CH2:4][C:5](=[O:22])[CH:6]([C:7]2[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=2)[CH:18]([N+:15]([O-:17])=[O:16])[CH3:19])[CH2:3][CH2:2]1

Participants

Reactant 4

HCID 887Methanol

HCID 6587Nitroethane

HCID 3362042HCID 3362042, compound

HCID 5360545Sodium

Product 1

HCID 57125898HCID 57125898, compound

Procedure

The procedure of Example IX using 32.1 g of 1-cyclopropyl-3-(p-methylphenyl)prop-2-en-1-one, 16.5 ml of nitroethane and 2.1 g of sodium in 170 ml of methanol gives 32 g of 1-cyclopropyl-3-(p-methylphenyl)-4-nitropentanone which is used in the crude state for the remainder of the operations.

Sources & evidence

ORD record: ord-080357f21aad40c69124858081bdcc75
Source dataset: uspto-grants-1977_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04005103

Reaction notes

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