Potassium Carbonate → HCID 21482950, compound

HRID 1415538Notes

Reaction equation

HRID 1415538 reaction equation
Cl.[N:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[S:12][C:11]2=[N:13][CH2:14][CH2:15][N:10]2[CH2:9]1.C(=O)([O-])[O-].[K+].[K+]>O>[N:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[S:12][C:11]2=[N:13][CH2:14][CH2:15][N:10]2[CH2:9]1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 21482949HCID 21482949, compound

Product 1

HCID 21482950HCID 21482950, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The hydrochloride is dissolved in water (12 cc.) and anhydrous potassium carbonate (3.9 g.) is added. The mixture is extracted with ethyl acetate (40 cc.) and the extracts are dried over anhydrous potassium carbonate. After filtration, the solvent is evaporated under reduced pressure (300 mm.Hg) and an oil (4 g.) is obtained which crystallises after treatment with cyclohexane (700 cc.). 2-(2-Pyridyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole (3.1 g.), melting at 70° C., is thus obtained.

Workup

  1. extractionThe mixture is extracted with ethyl acetate (40 cc.)
  2. dry with materialthe extracts are dried over anhydrous potassium carbonate
  3. filtrationAfter filtration
  4. customthe solvent is evaporated under reduced pressure (300 mm.Hg)
  5. customan oil (4 g.) is obtained which
  6. customcrystallises after treatment with cyclohexane (700 cc.)

Sources & evidence

ORD record
ord-08b6fcb0d347496f8bcd147f09c7e5d6
Source dataset
uspto-grants-1977_01
Patent number
US04005212

Reaction notes

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