Phthalimide → HCID 21482284, compound

HRID 1415607Notes

Reaction equation

HRID 1415607 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:31])[C:9]1[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:12]=[CH:11][C:10]=1[N:19]1[C:23]([CH2:24]O)=[C:22]([CH3:26])[N:21]=[C:20]1[CH2:27][N:28]([CH3:30])[CH3:29].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[C:51]1(=[O:61])[NH:55][C:54](=[O:56])[C:53]2=[CH:57][CH:58]=[CH:59][CH:60]=[C:52]12.N(C(OCC)=O)=NC(OCC)=O>>[F:17][C:15]([F:16])([F:18])[C:13]1[CH:12]=[CH:11][C:10]([N:19]2[C:23]([CH2:24][N:55]3[C:51](=[O:61])[C:52]4=[CH:60][CH:59]=[CH:58][CH:57]=[C:53]4[C:54]3=[O:56])=[C:22]([CH3:26])[N:21]=[C:20]2[CH2:27][N:28]([CH3:30])[CH3:29])=[C:9]([C:8](=[O:31])[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])[CH:14]=1

Participants

5

Reactant 4

HCID 6809PhthalimideHCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 21482294HCID 21482294, compound

Product 1

HCID 21482284HCID 21482284, compound

Procedure

In the manner given in Example 3, 2'-chloro-5-trifluoromethyl-2-[2-[(dimethylamino)methyl]-4-methyl-5-hyroxymethylimidazol-1-yl]benzophenone, triphenylphosphine, phthalimide and thereafter diethyl azodicarboxylate are reacted together to give N-[[1-[4-trifluoromethyl-2-(o-chlorobenzoyl)phenyl]-2-[(dimethylamino)methyl]-4-methylimidazol-5-yl]methyl]phthalimide.

Sources & evidence

ORD record
ord-558cd2e15e11417ea8dab1e1a2f60f98
Source dataset
uspto-grants-1977_01
Patent number
US04005099

Reaction notes

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