Phthalimide → HCID 21482282, compound

HRID 1415609Notes

Reaction equation

HRID 1415609 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9](=[O:29])[C:10]1[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:11]=1[N:17]1[C:21]([CH2:22]O)=[C:20]([CH3:24])[N:19]=[C:18]1[CH2:25][N:26]([CH3:28])[CH3:27].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[C:49]1(=[O:59])[NH:53][C:52](=[O:54])[C:51]2=[CH:55][CH:56]=[CH:57][CH:58]=[C:50]12.N(C(OCC)=O)=NC(OCC)=O>>[Cl:16][C:14]1[CH:13]=[CH:12][C:11]([N:17]2[C:21]([CH2:22][N:53]3[C:49](=[O:59])[C:50]4=[CH:58][CH:57]=[CH:56][CH:55]=[C:51]4[C:52]3=[O:54])=[C:20]([CH3:24])[N:19]=[C:18]2[CH2:25][N:26]([CH3:28])[CH3:27])=[C:10]([C:9](=[O:29])[C:3]2[C:4]([F:8])=[CH:5][CH:6]=[CH:7][C:2]=2[F:1])[CH:15]=1

Participants

5

Reactant 4

HCID 6809PhthalimideHCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 21482312HCID 21482312, compound

Product 1

HCID 21482282HCID 21482282, compound

Procedure

In the manner given in Example 3, 2',6'-difluoro-5-chloro-2-[2-[(dimethylamino)methyl]-4-methyl-5-hydroxymethylimidazol-1-yl]benzophenone, triphenylphosphine, phthalimide and thereafter diethyl azodicarboxylate are reacted together to give N-[[1-[4-chloro-2-(2,6-difluorobenzoyl)phenyl]-2-[(dimethylamino)methyl]-4-methylimidazol-5-yl]methyl]phthalimide.

Sources & evidence

ORD record
ord-d9034ebb650c42f68583b8b33d0c75a3
Source dataset
uspto-grants-1977_01
Patent number
US04005099

Reaction notes

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