Phthalimide → HCID 21482275, compound

HRID 1415611Notes

Reaction equation

HRID 1415611 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:27])[C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[N:16]1[C:20]([CH2:21]O)=[CH:19][N:18]=[C:17]1[CH2:23][N:24]([CH3:26])[CH3:25].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[C:47]1(=[O:57])[NH:51][C:50](=[O:52])[C:49]2=[CH:53][CH:54]=[CH:55][CH:56]=[C:48]12.N(C(OCC)=O)=NC(OCC)=O>>[F:15][C:13]1[CH:12]=[CH:11][C:10]([N:16]2[C:20]([CH2:21][N:51]3[C:47](=[O:57])[C:48]4=[CH:56][CH:55]=[CH:54][CH:53]=[C:49]4[C:50]3=[O:52])=[CH:19][N:18]=[C:17]2[CH2:23][N:24]([CH3:25])[CH3:26])=[C:9]([C:8](=[O:27])[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[F:1])[CH:14]=1

Participants

5

Reactant 4

HCID 6809PhthalimideHCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 21482277HCID 21482277, compound

Product 1

HCID 21482275HCID 21482275, compound

Procedure

In the manner given in Example 3, 2',5-difluoro-2-[2-[(dimethylamino)methyl]-5-hydroxymethylimidazol-1-yl]-benzophenone, triphenylphosphine, phthalimide and thereafter diethyl azodicarboxylate are reacted together to give N-[[1-[4-fluoro-2-(o-fluorobenzoyl)phenyl]-2-[(dimethylamino)methyl]imidazol-5-yl]methyl]phthalimide.

Sources & evidence

ORD record
ord-edf28cc6cc704e04a1dc4acad987548e
Source dataset
uspto-grants-1977_01
Patent number
US04005099

Reaction notes

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