Hydrochloric Acid → 1-Methoxycarbonyl-3-(2-dimethylaminoacetamidophenyl)thiourea hydrochloride

HRID 1415633Notes

Reaction equation

HRID 1415633 reaction equation
[CH3:1][O:2][C:3]([NH:5][C:6]([NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[NH:15][C:16](=[O:21])[CH2:17][N:18]([CH3:20])[CH3:19])=[S:7])=[O:4].[ClH:22]>C(O)C.C(OCC)C>[ClH:22].[CH3:1][O:2][C:3]([NH:5][C:6]([NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[NH:15][C:16](=[O:21])[CH2:17][N:18]([CH3:20])[CH3:19])=[S:7])=[O:4]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 212695841-Methoxycarbonyl-3-(2-dimethylaminoacetamidophenyl)thiourea

Product 1

HCID 212695831-Methoxycarbonyl-3-(2-dimethylaminoacetamidophenyl)thiourea hydrochloride

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 3283Diethyl EtherSolvent2×

Procedure

1-Methoxycarbonyl-3-(2-dimethylaminoacetamidophenyl)thiourea (3.0 g) was dissolved in the minimum quantity of ethanol and the solution treated with diethyl ether (300 ml), followed by an excess of a saturated solution of hydrogen chloride in diethyl ether. The resultant solid was filtered off and recrystallised from ethanol to give 1-methoxycarbonyl-3-(2-dimethylaminoacetamidophenyl)thiourea hydrochloride (2.8 g) m.p. 187°-188° C. (with decomposition).

Workup

  1. filtrationThe resultant solid was filtered off
  2. customrecrystallised from ethanol

Sources & evidence

ORD record
ord-9dad1af15ad0463db35b4d3ebd2659f5
Source dataset
uspto-grants-1977_01
Patent number
US04005217

Reaction notes

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