Hydrochloric Acid → 1-Ethoxycarbonyl-3-(2-dimethylaminoacetamidophenyl)thiourea hydrochloride

HRID 1415639Notes

Reaction equation

HRID 1415639 reaction equation
[CH2:1]([O:3][C:4]([NH:6][C:7]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[NH:16][C:17](=[O:22])[CH2:18][N:19]([CH3:21])[CH3:20])=[S:8])=[O:5])[CH3:2].[ClH:23]>C(O)C.C(OCC)C>[ClH:23].[CH2:1]([O:3][C:4]([NH:6][C:7]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[NH:16][C:17](=[O:22])[CH2:18][N:19]([CH3:21])[CH3:20])=[S:8])=[O:5])[CH3:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 214829821-Ethoxycarbonyl-3-(2-dimethylaminoacetamidophenyl)thiourea

Product 1

HCID 214830631-Ethoxycarbonyl-3-(2-dimethylaminoacetamidophenyl)thiourea hydrochloride

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 3283Diethyl EtherSolvent2×

Procedure

1-Ethoxycarbonyl-3-(2-dimethylaminoacetamidophenyl)thiourea (5.0 g) was dissolved in the minimum quantity of ethanol and the solution treated with diethyl ether (500 ml), followed by a saturated solution of hydrogen chloride in diethyl ether. The resultant solid was filtered off and recrystallised from ethanol/diethyl ether to give 1-ethoxycarbonyl-3-(2-dimethylaminoacetamidophenyl)thiourea hydrochloride (4.3 g), m.p. 178°-180° C. (with decomposition).

Workup

  1. filtrationThe resultant solid was filtered off
  2. customrecrystallised from ethanol/diethyl ether

Sources & evidence

ORD record
ord-eb1be748e62f42b9af18701679b19d15
Source dataset
uspto-grants-1977_01
Patent number
US04005217

Reaction notes

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