Trimethylsilyl cyanide → alpha-(2,4-Difluoroanilino)-alpha-(4-sulfamoylphenyl)acetonitrile

HRID 1415812Notes

Reaction equation

HRID 1415812 reaction equation
[F:1][C:2]1[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:3]=1[N:4]=[CH:5][C:6]1[CH:11]=[CH:10][C:9]([S:12](=[O:15])(=[O:14])[NH2:13])=[CH:8][CH:7]=1.C[Si]([C:25]#[N:26])(C)C>>[F:1][C:2]1[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:3]=1[NH:4][CH:5]([C:6]1[CH:7]=[CH:8][C:9]([S:12](=[O:15])(=[O:14])[NH2:13])=[CH:10][CH:11]=1)[C:25]#[N:26]

Participants

3

Reactant 2

HCID 82115Trimethylsilyl cyanideHCID 218627832,4-Difluoro-N-(4-sulfamoylbenzylidene)aniline

Product 1

HCID 21862810alpha-(2,4-Difluoroanilino)-alpha-(4-sulfamoylphenyl)acetonitrile

Procedure

Following a procedure similar to that described in Example 1(ii), but using 2,4-difluoro-N-(4-sulfamoylbenzylidene)aniline [prepared as described in step (i) above] and trimethylsilyl cyanide as starting materials, the title compound was obtained as a white powder (yield 100%).

Sources & evidence

ORD record
ord-79c74f12e8af4047a120e45302552899
Source dataset
uspto-grants-1999_06
Patent number
US05908858

Reaction notes

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