Water → N-(n-butyl)-1,2,3,4-tetrahydro-2,3-dioxo-6-quinoxaline sulfonamide

HRID 1416156Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1416156
[CH2:1]([NH2:5])[CH2:2][CH2:3][CH3:4].O.[O:7]=[C:8]1[C:17](=[O:18])[NH:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([S:19](Cl)(=[O:21])=[O:20])[CH:14]=2)[NH:9]1>>[CH2:1]([NH:5][S:19]([C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8](=[O:7])[C:17](=[O:18])[NH:16]2)(=[O:20])=[O:21])[CH2:2][CH2:3][CH3:4]

Komponenten

4

Edukt 3

HCID 962WaterHCID 8007ButylamineHCID 49837382,3-Dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonyl chloride

Produkt 1

HCID 17654101N-(n-butyl)-1,2,3,4-tetrahydro-2,3-dioxo-6-quinoxaline sulfonamideAusbeute 76 %

Versuchsvorschrift

To a solution of 7.31 g (0.1 mole) of n-butylamine in 20 ml of water 5.21 g (0.02 mole) of 1,2,3,4-tetrahydro-2,3-dioxo-6-quinoxalinesulfonyl chloride are added, and the mixture is stirred at room temperature for 5 hours. Then it is allowed to stand for 16 hours, the separated crystals are filtered off, washed with water, dried and recrystallized from acetone. Thus 4.50 g (76%) of N-(n-butyl)-1,2,3,4-tetrahydro-2,3-dioxo-6-quinoxaline sulfonamide are obtained, m.p.: 257-262° C.

Aufarbeitung

  1. waitto stand for 16 hours
  2. filtrationthe separated crystals are filtered off
  3. washwashed with water
  4. customdried
  5. customrecrystallized from acetone

Quellen und Nachweise

ORD-Eintrag
ord-a58fa20593114f35b5a6fd8f3353f5c5
Quelldatensatz
uspto-grants-1999_06
Patentnummer
US05912245

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