反应详情

温度

40 °C

To a mixture of 1H-indazole-6-carboxylic acid (1.0 g) in methylene chloride (15 mL) was added EDC (1.8 g), HOBT (1.27 g), and triethylamine (1.29 mL). The mixture was heated to 40° C. for 30 minutes at which time methanol (10.0 mL) was added. The mixture was stirred at 40° C. for 18 h. The mixture was removed from heat, cooled to room temperature and poured into methylene chloride. The mixture was washed twice with water then brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 0.955 g of the title compound: 1H NMR (CDCl3) δ 3.98, 7.81, 7.86, 8.16, 8.29, 10.6.

1. additionwas added
2. customThe mixture was removed
3. temperaturefrom heat
4. temperaturecooled to room temperature
5. additionpoured into methylene chloride
6. washThe mixture was washed twice with water
7. dry with materialbrine, dried over anhydrous sodium sulfate
8. concentrationconcentrated under reduced pressure