Hydrochloric Acid → HCID 70102972, compound

HRID 1416331Notes

Reaction equation

HRID 1416331 reaction equation
[CH2:1]([O:3][C:4]([C@@H:6]1[CH2:11][CH2:10][CH2:9][N:8]([CH2:12][CH2:13][CH:14]=[C:15]2[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[O:20][CH2:19][O:18][C:17]3[CH:27]=[CH:28][CH:29]=[CH:30][C:16]2=3)[CH2:7]1)=[O:5])[CH3:2].[ClH:31].CCOCC>O1CCCC1>[ClH:31].[CH2:1]([O:3][C:4]([C@@H:6]1[CH2:11][CH2:10][CH2:9][N:8]([CH2:12][CH2:13][CH:14]=[C:15]2[C:16]3[CH:30]=[CH:29][CH:28]=[CH:27][C:17]=3[O:18][CH2:19][O:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]2=3)[CH2:7]1)=[O:5])[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 70102673HCID 70102673, compound

Product 1

HCID 70102972HCID 70102972, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

(R)-1-(3-(12H-Dibenzo[d,g][1,3]dioxocin-12-ylidene)-1-propyl)-3-piperidinecarboxylic acid ethyl ester (0.86 g, 2.1 mmol, prepared as described in example 2) was dissolved in tetrahydrofuran (10 ml) and a 2.6N solution of hydrogen chloride in ether (0.97 ml, 2.52 mmol) was added dropwise. The solution was evaporated in vacuo and the remainder was treated with ether (20 ml). The precipitate was filtered off, washed with ether and dried in vacuo, affording the title compound as a powder.

Workup

  1. customThe solution was evaporated in vacuo
  2. additionthe remainder was treated with ether (20 ml)
  3. filtrationThe precipitate was filtered off
  4. washwashed with ether
  5. customdried in vacuo

Sources & evidence

ORD record
ord-78c1fbfaf7fe4b9b8311201376a2552b
Source dataset
uspto-grants-1999_06
Patent number
US05912262

Reaction notes

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