反应详情

In 30 ml of N,N-dimethylformamide, 3.63 g of 5-ethyl-2-imino-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1,3,4-thiadiazoline was dissolved, followed by the addition of 1.44 g of 1-cyclopentene-1,2-dicarboxylic anhydride. The resulting mixture was stirred at room temperature for 6 hours. To the reaction mixture, 200 ml of water and 5 ml of hydrochloric acid were added. The powders so precipitated were collected by filtration. The powders so obtained were suspended in 100 ml of ethanol and the resulting suspension was heated under reflux for 20 minutes. The powders were collected by filtration, washed successively with ethanol and diethyl ether and then dried, whereby 4.53 g of the title compound was obtained.

1. customThe powders so precipitated
2. filtrationwere collected by filtration
3. customThe powders so obtained
4. temperaturethe resulting suspension was heated
5. temperatureunder reflux for 20 minutes
6. filtrationThe powders were collected by filtration
7. washwashed successively with ethanol and diethyl ether
8. customdried